Treating cancer by inhibiting angiogenesis: New hopes and potential pitfalls

被引：57

作者：

Rak, J ^{[1
]}

Kerbel, RS ^{[1
]}

机构：

[1] SUNNYBROOK HLTH SCI CTR,DIV CANC BIOL RES,TORONTO,ON M4N 3M5,CANADA

来源：

CANCER AND METASTASIS REVIEWS | 1996年 / 15卷 / 02期

关键词：

angiogenesis dependence; oncogenes; VEGF;

D O I：

10.1007/BF00437476

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis is essential for progressive solid tumor growth and thus constitutes a very promising therapeutic target. Recent developments in understanding of the molecular mechanisms involved in tumor blood vessel formation provides a rational basis for anti-angiogenic drug development, especially of more selective and effective agents. However, for the very same reason, it is time to think more critically about some of the potential pitfalls and difficulties associated with this treatment strategy and of research needed to define realistic expectations in this area.

引用

页码：231 / 236

页数：6

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