Quantitative determination of domperidone in rat plasma by high-performance liquid chromatography with fluorescence detection

被引:44
作者
Yamamoto, K
Hagino, M
Kotaki, H
Iga, T
机构
[1] Tokyo Univ Hosp, Fac Med, Dept Pharm, Bunkyo Ku, Tokyo 113, Japan
[2] Univ Tokyo, Inst Med Sci, Dept Pharm, Res Hosp,Minato Ku, Tokyo 108, Japan
来源
JOURNAL OF CHROMATOGRAPHY B | 1998年 / 720卷 / 1-2期
关键词
domperidone;
D O I
10.1016/S0378-4347(98)00339-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A sensitive and selective analytical method for the determination of domperidone in rat plasma is described. The procedure involves liquid-liquid extraction followed by reversed-phase high-performance chromatographic analysis with fluorometric detection at 282 nm for excitation and 328 nm for emission. The detection limit was 1 ng ml(-1) using 1 mi of plasma. This assay procedure should be useful for the pharmacokinetic study of domperidone in small animals such as rats. (C) 1998 Elsevier Science B.V; All rights reserved.
引用
收藏
页码:251 / 255
页数:5
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