The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines

被引：106

作者：

Krakauer, T

Li, BQ

Young, HA

机构：

[1] USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Frederick, MD 21702 USA

[2] SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA

[3] NCI, Expt Immunol Lab, Frederick, MD 21702 USA

来源：

FEBS LETTERS | 2001年 / 500卷 / 1-2期

关键词：

immunosuppression; superantigen; cytokine and chemokine; baicalin; flavonoid;

D O I：

10.1016/S0014-5793(01)02584-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Excessive release of proinflammatory cytokines mediates the rode effect of superantigenic staphylococcal exotoxins (SE). Baicalin, a flavone isolated from the Chinese herb Scutellaria baicalensis Georgi and used in China to treat infectious diseases, inhibited SE-stimulated T-cell proliferation (by 98%) and production of interleukin 1 beta, interleukin 6, tumor necrosis factor, interferon gamma, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)-1 alpha, and MIP-1 beta mRNA and protein by human peripheral blood mononuclear cells, These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens, (C) 2001 Federation of European Biochemieal Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：52 / 55

页数：4

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