Immunity to Bordetella pertussis

被引：170

作者：

Mills, KHG ^{[1
]}

机构：

[1] Natl Univ Ireland, Dept Biol, Infect & Immun Grp, Maynooth, Kildare, Ireland

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 08期

基金：

英国惠康基金;

关键词：

Bordetella pertussis; pertussis vaccine; protective immunity; Th1; Th2; Tr1; cell; immunological memory; immune subversion; neurological response;

D O I：

10.1016/S1286-4579(01)01421-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and a variety of immune evasion strategies to prolong its survival in the host. This article reviews evidence of complementary roles for cellular and humoral immunity in protection. It discusses the effector mechanisms of bacterial elimination, the strategies employed by the bacteria to subvert protective immune responses and the immunological basis for systemic and neurological responses to infection and vaccination. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：655 / 677

页数：23

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