High-performance liquid chromatographic determination of paclitaxel in rat serum:: application to a toxicokinetic study

被引:25
作者
Coudoré, F [1 ]
Authier, N
Guillaume, D
Béal, A
Duroux, E
Fialip, J
机构
[1] Fac Pharm Clermont Ferrand, Equipe NPPUA, Toxicol Lab, F-63001 Clermont Ferrand, France
[2] Fac Pharm Clermont Ferrand, Equipe NPPUA, Pharmacol Lab, F-63001 Clermont Ferrand, France
来源
JOURNAL OF CHROMATOGRAPHY B | 1999年 / 721卷 / 02期
关键词
paclitaxel; Taxol (R);
D O I
10.1016/S0378-4347(98)00465-4
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A simple and sensitive high-performance liquid chromatographic method is described for the determination of paclitaxel (Taxol(R)) at 230 nm using a Nucleosil C-18 (5 mu m) column and a methanol-water (70:30, v/v) mobile phase following a single-step extraction from serum with dichloromethane. The assay was validated against the classical criteria and was applied to a toxicokinetic study in rats after one or five, (one per week) intraperitoneal administrations of 16 mg/kg Taxol(R). (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:317 / 320
页数:4
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