High-performance liquid chromatographic determination of paclitaxel in rat serum:: application to a toxicokinetic study

被引：25

作者：

Coudoré, F ^{[1
]}

Authier, N

Guillaume, D

Béal, A

Duroux, E

Fialip, J

机构：

[1] Fac Pharm Clermont Ferrand, Equipe NPPUA, Toxicol Lab, F-63001 Clermont Ferrand, France

[2] Fac Pharm Clermont Ferrand, Equipe NPPUA, Pharmacol Lab, F-63001 Clermont Ferrand, France

来源：

JOURNAL OF CHROMATOGRAPHY B | 1999年 / 721卷 / 02期

关键词：

paclitaxel; Taxol (R);

D O I：

10.1016/S0378-4347(98)00465-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and sensitive high-performance liquid chromatographic method is described for the determination of paclitaxel (Taxol(R)) at 230 nm using a Nucleosil C-18 (5 mu m) column and a methanol-water (70:30, v/v) mobile phase following a single-step extraction from serum with dichloromethane. The assay was validated against the classical criteria and was applied to a toxicokinetic study in rats after one or five, (one per week) intraperitoneal administrations of 16 mg/kg Taxol(R). (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：317 / 320

页数：4

共 13 条

[1]

BEIJNEN JH, 1994, SEMIN ONCOL, V21, P53

[2] EXPERIMENTAL PERIPHERAL NEUROPATHY INDUCED IN ADULT-RATS BY REPEATED INTRAPERITONEAL ADMINISTRATION OF TAXOL [J].

CAVALETTI, G ;

TREDICI, G ;

BRAGA, M ;

TAZZARI, S .

EXPERIMENTAL NEUROLOGY, 1995, 133 (01) :64-72

[3]

EISEMAN JL, 1994, CANCER CHEMOTH PHARM, V34, P465, DOI 10.1007/BF00685656

[4] Determination of paclitaxel in biological fluids by micellar electrokinetic chromatography [J].

Hempel, G ;

Lehmkuhl, D ;

Krumpelmann, S ;

Blaschke, G ;

Boos, J .

JOURNAL OF CHROMATOGRAPHY A, 1996, 745 (1-2) :173-179

[5]

INNOCENTI F, 1995, DRUG METAB DISPOS, V23, P713

[6]

LONGNECKER SM, 1987, CANCER TREAT REP, V71, P53

[7]

MARTIN N, 1996, B CANC, V83, P122

[8] ANALYSIS OF ANTICANCER DRUGS IN BIOLOGICAL-FLUIDS - DETERMINATION OF TAXOL WITH APPLICATION TO CLINICAL PHARMACOKINETICS [J].

RIZZO, J ;

RILEY, C ;

VONHOFF, D ;

KUHN, J ;

PHILLIPS, J ;

BROWN, T .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (02) :159-164

[9] REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF TAXOL IN MOUSE PLASMA [J].

SHARMA, A ;

CONWAY, WD ;

STRAUBINGER, RM .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1994, 655 (02) :315-319

[10]

SONG D, 1995, J CHROMATOGR B, V663, P337

← 1 2 →