HIV-1 variation before seroconversion in men who have sex with men: Analysis of acute/early HIV infection in the multicenter AIDS cohort study

被引：54

作者：

Gottlieb, Geoffrey S. ^{[1
]}

Heath, Laura ^{[2
]}

Nickle, David C. ^{[2
]}

Wong, Kim G. ^{[2
]}

Leach, Stephanie E. ^{[2
]}

Jacobs, Benjamin ^{[2
]}

Gezahegne, Surafel ^{[2
]}

van 't Wout, Angelique B. ^{[2
]}

Jacobson, Lisa P. ^{[3
]}

Margolick, Joseph B. ^{[4
]}

Mullins, James I. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[2] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 07期

关键词：

D O I：

10.1086/529206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Understanding the characteristics of human immunodeficiency virus ( HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome ( AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity ( 0.2%-5.6% [ median, 0.86%]), V1-V2 loop length ( 58-93 aa), and potential N-linked glycosylation sites ( n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count < 200 cells/mu L.

引用

页码：1011 / 1015

页数：5

共 15 条

[1] Selection for human immunodeficiency virus type I envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
Chohan, B
Lang, D
Sagar, M
Korber, B
Lavreys, L
Richardson, B
Overbaugh, J
[J]. JOURNAL OF VIROLOGY, 2005, 79 (10) : 6528 - 6531
[2] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EVOLUTION IN-VIVO TRACKED BY DNA HETERODUPLEX MOBILITY ASSAYS
DELWART, EL
SHEPPARD, HW
WALKER, BD
GOUDSMIT, J
MULLINS, JI
[J]. JOURNAL OF VIROLOGY, 1994, 68 (10) : 6672 - 6683
[3] Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
Derdeyn, CA
Decker, JM
Bibollet-Ruche, F
Mokili, JL
Muldoon, M
Denham, SA
Heil, ML
Kasolo, F
Musonda, R
Hahn, BH
Shaw, GM
Korber, BT
Allen, S
Hunter, E
[J]. SCIENCE, 2004, 303 (5666) : 2019 - 2022
[4] Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
Gray, RH
Wawer, MJ
Brookmeyer, R
Sewankambo, NK
Serwadda, D
Wabwire-Mangen, F
Lutalo, T
Li, XB
vanCott, T
Quinn, TC
[J]. LANCET, 2001, 357 (9263) : 1149 - 1153
[5] Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new host
Herbeck, JT
Nickle, DC
Learn, GH
Gottlieb, GS
Curlin, ME
Heath, L
Mullins, JI
[J]. JOURNAL OF VIROLOGY, 2006, 80 (04) : 1637 - 1644
[6] Virus population homogenization following acute human immunodeficiency virus type 1 infection
Learn, GH
Muthui, D
Brodie, SJ
Zhu, TF
Diem, K
Mullins, JI
Corey, L
[J]. JOURNAL OF VIROLOGY, 2002, 76 (23) : 11953 - 11959
[7] HIV quasispecies and resampling
Liu, SL
Rodrigo, AG
Shankarappa, R
Learn, GH
[J]. SCIENCE, 1996, 273 (5274) : 415 - 416
[8] Long EM, 2000, NAT MED, V6, P71
[9] Intrapatient diversity and its correlation with viral setpoint in human immunodeficiency virus type 1 CRF02_A/G-IbNG infection
Mani, I
Gilbert, P
Sankalé, JL
Eisen, G
Mboup, S
Kanki, PJ
[J]. JOURNAL OF VIROLOGY, 2002, 76 (21) : 10745 - 10755
[10] Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline
Markham, RB
Wang, WC
Weisstein, AE
Wang, Z
Munoz, A
Templeton, A
Margolick, J
Vlahov, D
Quinn, T
Farzadegan, H
Yu, XF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) : 12568 - 12573

← 1 2 →