Family history of early cardiovascular disease in children with moderate to severe hypercholesterolemia: Relationship to lipoprotein (a) and low-density lipoprotein cholesterol levels

被引:12
作者
Barth, JA
Deckelbaum, RJ
Starc, TJ
Shea, S
Mosca, L
Berglund, L
机构
[1] Columbia Presbyterian Med Ctr, Dept Pediat, New York, NY 10032 USA
[2] Columbia Presbyterian Med Ctr, Dept Med, New York, NY 10032 USA
来源
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1999年 / 133卷 / 03期
关键词
D O I
10.1016/S0022-2143(99)90079-3
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Lipoprotein (a) (Lp(a)) is an established cardiovascular risk factor in adults. We sought to evaluate whether raised Lp(a) levels were predictive of a family history of early cardiovascular disease (CVD) in children already at increased risk for premature atherosclerosis because of elevated low-density lipoprotein (LDL) cholesterol levels, Lp(a) and serum lipid levels were measured in 69 children and offspring with established moderate to severe hypercholesterolemia (serum cholesterol >170 mg/dL) who were aged 10.7 +/- 4.3 years (range 1.5 to 21 years) and had been referred to a pediatric lipid center. The children represented families with a positive (n = 27) or negative (n = 42) history for premature CVD (<55 years of age in parent or grandparent), In all children, Lp(a) levels ranged from 1 to 140 mg/dL, with a median of 29 mg/dL. Mean total cholesterol, LDL cholesterol, and high-density lipoprotein (HDL) cholesterol levels were 234 mg/dL, 166 mg/dL, and 45 mg/dL, respectively. There was no difference in median Lp(a) levels between the children with a positive family history and those with a negative family history (29.9 mg/dL vs 29.0 mg/dL, respectively). In contrast, children with a positive family history showed significantly higher LDL cholesterol levels (186 +/- 61 mg/dL vs 153 +/- 52 mg/dL, P = .02). Thus, in this group of hypercholesterolemic children, LDL cholesterol but not Lp(a) levels were associated with a family history of premature CVD, Further studies are needed to identify additional specific risk factors associated with the development of CVD in this population.
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页码:237 / 244
页数:8
相关论文
共 66 条
[1]   LIPOPROTEIN(A) CONCENTRATION IN VARIOUS HYPERLIPIDEMIAS [J].
ALBERTY, R .
CLINICA CHIMICA ACTA, 1994, 226 (01) :105-107
[2]   RELATION OF SERUM HOMOCYSTEINE AND LIPOPROTEIN(A) CONCENTRATIONS TO ATHEROSCLEROTIC DISEASE IN A PROSPECTIVE FINNISH POPULATION-BASED STUDY [J].
ALFTHAN, G ;
PEKKANEN, J ;
JAUHIAINEN, M ;
PITKANIEMI, J ;
KARVONEN, M ;
TUOMILEHTO, J ;
SALONEN, JT ;
EHNHOLM, C .
ATHEROSCLEROSIS, 1994, 106 (01) :9-19
[3]   THE ASSOCIATION BETWEEN SERUM LP(A) CONCENTRATIONS AND ANGIOGRAPHICALLY ASSESSED CORONARY ATHEROSCLEROSIS - DEPENDENCE ON SERUM LDL LEVELS [J].
ARMSTRONG, VW ;
CREMER, P ;
EBERLE, E ;
MANKE, A ;
SCHULZE, F ;
WIELAND, H ;
KREUZER, H ;
SEIDEL, D .
ATHEROSCLEROSIS, 1986, 62 (03) :249-257
[4]  
BAILLEUL S, 1995, CLIN CHEM, V41, P241
[5]   FAMILY HISTORY OF HEART-ATTACK AS AN INDEPENDENT PREDICTOR OF DEATH DUE TO CARDIOVASCULAR-DISEASE [J].
BARRETTCONNOR, E ;
KHAW, K .
CIRCULATION, 1984, 69 (06) :1065-1069
[6]  
BERG K, 1979, CLIN GENET, V16, P347
[7]   Hormonal regulation of serum lipoprotein (a) levels: Effects of parenteral administration of estrogen or testosterone in males [J].
Berglund, L ;
Carlstrom, K ;
Stege, R ;
Gottlieb, C ;
Eriksson, M ;
Angelin, B ;
Henriksson, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (07) :2633-2637
[8]   SERUM-LIPID VALUES IN ADOLESCENTS ARE RELATED TO FAMILY HISTORY, INFANT-FEEDING, AND PHYSICAL GROWTH [J].
BERGSTROM, E ;
HERNELL, O ;
PERSSON, LA ;
VESSBY, B .
ATHEROSCLEROSIS, 1995, 117 (01) :1-13
[9]   APOLIPOPROTEIN(A) GENE ACCOUNTS FOR GREATER THAN 90-PERCENT OF THE VARIATION IN PLASMA LIPOPROTEIN(A) CONCENTRATIONS [J].
BOERWINKLE, E ;
LEFFERT, CC ;
LIN, JP ;
LACKNER, C ;
CHIESA, G ;
HOBBS, HH .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (01) :52-60
[10]   Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger - A prospective study [J].
Bostom, AG ;
Cupples, LA ;
Jenner, JL ;
Ordovas, JM ;
Seman, LJ ;
Wilson, PWF ;
Schaefer, EJ ;
Castelli, WP .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (07) :544-548