Domain formation in membranes caused by lipid wetting of protein

被引:31
作者
Akimov, Sergey A. [1 ,2 ]
Frolov, Vladimir A. J. [1 ,2 ]
Kuzmin, Peter I. [1 ,2 ]
Zimmerberg, Joshua [2 ]
Chizmadzhev, Yuri A. [1 ,2 ]
Cohen, Fredric S. [3 ]
机构
[1] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Lab Bioelectrochem, Moscow 119991, Russia
[2] NICHHD, Lab Cellular & Mol Biophys, Natl Inst Hlth, Bethesda, MD 20892 USA
[3] Rush Univ, Med Ctr, Dept Physiol & Mol Biophys, Chicago, IL 60612 USA
来源
PHYSICAL REVIEW E | 2008年 / 77卷 / 05期
关键词
D O I
10.1103/PhysRevE.77.051901
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
Formation of rafts and other domains in cell membranes is considered as wetting of proteins by lipids. The membrane is modeled as a continuous elastic medium. Thermodynamic functions of the lipid films that wet proteins are calculated using a mean-field theory of liquid crystals as adapted to biomembranes. This approach yields the conditions necessary for a macroscopic wetting film to form; its thickness could also be determined. It is shown that films of macroscopic thicknesses form around large (tens nanometers in diameter) lipid-protein aggregates; only thin adsorption films form around single proteins or small complexes. The means by which wetting films can facilitate the merger of these aggregates is considered. It is shown that a wetting film prevents a protein from leaving an aggregate. Using experimentally derived values of elastic moduli and spontaneous curvatures as well as height mismatch between aggregates and bulk membrane, we obtained numerical results, which can be compared with the experimental data.
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页数:17
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