CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin

被引：12

作者：

Ericsson, A

Arya, A

Agace, W

机构：

[1] Lund Univ, Dept Cell & Mol Biol, Immunol Sect, SE-22184 Lund, Sweden

[2] Enanta Pharmaceut Inc, Watertown, MA 02472 USA

来源：

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION | 2004年 / 1029卷

关键词：

CCL25; CD103; CD8(+) T cells; E-cadherin;

D O I：

10.1196/annals.1309.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our results demonstrate that (1) CD103 is upregulated on CD8(+) T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103-mediated adhesion to E-cadlierin. These results suggest a novel role for chemokines in modulating interactions between lymphocytes and epithelial cells at mucosal surfaces.

引用

页码：334 / 336

页数：3

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