Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide

被引：53

作者：

Harried, SS

Lee, CP

Yang, G

Lee, TIH

Myles, DC ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Kosan Biosci, Hayward, CA 94545 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 17期

关键词：

D O I：

10.1021/jo034521r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.

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页码：6646 / 6660

页数：15

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