Presence of key drug resistance mutations in isolates from untreated patients of Abidjan, Cote d'Ivoire: ANRS 1257 study

被引：29

作者：

Toni, TD

Recordon-Pinson, P

Minga, A

Ekouevi, D

Bonard, D

Bequet, L

Huet, C

Chenal, H

Rouet, F

Dabis, F

Lafon, ME

Salamon, R

Masquelier, B

Fleury, HJ

机构：

[1] Univ Bordeaux 2, F-33076 Bordeaux, France

[2] CIRBA, Abidjan, Cote Ivoire

[3] PAC CI, Abidjan, Cote Ivoire

[4] CeDRes, Abidjan, Cote Ivoire

[5] INSERM, U330, Bordeaux, France

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2003年 / 19卷 / 08期

关键词：

D O I：

10.1089/088922203322280946

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 107 HIV-1 isolates from untreated adult patients recruited in Abidjan, Cote d'Ivoire, in 2001 and 2002 were sequenced in the env, reverse transcriptase (RT), and protease genes. The results show that CRF02_AG is still predominant in this west African population; key mutations of resistance to antiretroviral drugs (NRTI, NNRTI, and PIs) were detected in 5.6% of the patients. We hypothesize that these resistant mutants have been acquired through horizontal transmission. Compared to a previous study carried out by our group in 1997-2000 in a similar population of Abidjan, it seems that there is a dynamic process of resistance and that a survey will be necessary.

引用

页码：713 / 717

页数：5

共 11 条

[1]

Adjé C, 2001, J ACQ IMMUN DEF SYND, V26, P501, DOI 10.1097/00126334-200104150-00018

[2] Reduced susceptibility of human immunodeficiency virus type 1 (HIV-1) from patients with primary HIV infection to nonnucleoside reverse transcriptase inhibitors is associated with variation at novel amino acid sites [J].

Brown, AJL ;

Precious, HM ;

Whitcomb, JM ;

Wong, JK ;

Quigg, M ;

Huang, W ;

Daar, ES ;

D'Aquila, RT ;

Keiser, PH ;

Connick, E ;

Hellmann, NS ;

Petropoulos, CJ ;

Richman, DD ;

Little, SJ .

JOURNAL OF VIROLOGY, 2000, 74 (22) :10269-10273

[3] Generation of a consensus sequence from prevalent and incident HIV-1 infections in West Africa to guide AIDS vaccine development [J].

Ellenberger, DL ;

Li, B ;

Lupo, LD ;

Owen, SM ;

Nkengasong, J ;

Kadio-Morokro, MS ;

Smith, J ;

Robinson, H ;

Ackers, M ;

Greenberg, A ;

Folks, T ;

Butera, S .

VIROLOGY, 2002, 302 (01) :155-163

[4] No difference in clinical progression between patients infected with the predominant human immunodeficiency virus type 1 circulating recombinant form (CRF) 02_AG strain and patients not infected with CRF02_AG, in western and west-central Africa:: A four-year prospective multicenter study [J].

Laurent, C ;

Bourgeois, A ;

Faye, MA ;

Mougnutou, R ;

Seydi, M ;

Gueye, M ;

Liégeois, F ;

Kane, CT ;

Butel, C ;

Mbuagbaw, J ;

Zekeng, L ;

Mboup, S ;

Mpoudi-Ngolé, E ;

Peeters, M ;

Delaporte, E .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (04) :486-492

[5] Predominance of CRF02-AG and CRF06-cpx in Niger, west Africa [J].

Mamadou, S ;

Montavon, C ;

Ben, A ;

Djibo, A ;

Rabiou, S ;

Mboup, S ;

Delaporte, E ;

Peeters, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2002, 18 (10) :723-726

[6]

Montavon C, 2000, J ACQ IMMUN DEF SYND, V23, P363

[7]

Montavon C, 2002, J ACQ IMMUN DEF SYND, V29, P522, DOI 10.1097/00126334-200204150-00014

[8]

Salamon R, 2002, J ACQ IMMUN DEF SYND, V29, P149, DOI 10.1097/00042560-200202010-00007

[9]

Sankalé JL, 2000, J HUMAN VIROL, V3, P157

[10] Primary HIV-1 drug resistance in Abidjan (Cote d'Ivoire):: a genotypic and phenotypic study [J].

Toni, TD ;

Masquelier, B ;

Bonard, D ;

Faure, M ;

Huët, C ;

Caumont, A ;

Roques, P ;

Dabis, F ;

Salamon, R ;

Fleury, H .

AIDS, 2002, 16 (03) :488-491

← 1 2 →