A suicide note from Alzheimer disease neurons?

被引:96
作者
Perry, G [1 ]
Nunomura, A [1 ]
Smith, MA [1 ]
机构
[1] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA
关键词
D O I
10.1038/nm0898-897
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
New findings implicate apoptosis in the death of neurons in Alzheimer disease but the evidence is still insufficient to formally indict apoptosis in the neurodegeneration associated with this disease (pages 957–962).
引用
收藏
页码:897 / 898
页数:2
相关论文
共 7 条
  • [1] Mechanisms of neuronal death in Alzheimer's disease
    Cotman, CW
    Su, JH
    [J]. BRAIN PATHOLOGY, 1996, 6 (04) : 493 - 506
  • [2] Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
    Guo, Q
    Fu, WM
    Xie, J
    Luo, H
    Sells, SF
    Geddes, JW
    Bondada, V
    Rangnekar, VM
    Mattson, MP
    [J]. NATURE MEDICINE, 1998, 4 (08) : 957 - 962
  • [3] APP(Sw) transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
    Irizarry, MC
    McNamara, M
    Fedorchak, K
    Hsiao, K
    Hyman, BT
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (09) : 965 - 973
  • [4] Oxidative damage in Alzheimer's
    Smith, MA
    Perry, G
    Richey, PL
    Sayre, LM
    Anderson, VE
    Beal, MF
    Kowall, N
    [J]. NATURE, 1996, 382 (6587) : 120 - 121
  • [5] Alzheimer disease:: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
    Stadelmann, C
    Brück, W
    Bancher, C
    Jellinger, K
    Lassmann, H
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (05) : 456 - 464
  • [6] Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
    Su, JH
    Deng, GM
    Cotman, CW
    [J]. BRAIN RESEARCH, 1997, 774 (1-2) : 193 - 199
  • [7] Copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical
    Tsang, SY
    Tam, SC
    Bremner, I
    Burkitt, MJ
    [J]. BIOCHEMICAL JOURNAL, 1996, 317 : 13 - 16