Radiologic progression in patients with juvenile chronic arthritis treated with methotrexate

被引：50

作者：

Ravelli, A

Viola, S

Ramenghi, B

Beluffi, G

Zonta, LA

Martini, A

机构：

[1] Univ Pavia, Pediat Clin, Ist Ricovero & Cura Carattere Sci, Policlin San Matteo, I-27100 Pavia, Italy

[2] Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

[3] Univ Pavia, Pediat Clin, I-27100 Pavia, Italy

来源：

JOURNAL OF PEDIATRICS | 1998年 / 133卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(98)70231-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We investigated the rate of radiologic progression, as measured by carpal length, in 26 children with juvenile chronic arthritis who were treated with methotrexate. After 2 years of treatment, the carpal length was significantly more deteriorated in nonresponders in both the "better" wrist (P = .001) and the "worse" wrist (P = .005). These results show that methotrexate may have a "disease modifying" potential in juvenile chronic arthritis.

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页码：262 / 265

页数：4

相关论文

共 13 条

[1] THE EXPERIENCE OF BEREAVEMENT IN OLDER ADULTS [J].

ANDERSON, KL ;

DIMOND, MF .

JOURNAL OF ADVANCED NURSING, 1995, 22 (02) :308-315

[2] ANTIRHEUMATIC DRUGS - A PROPOSED NEW CLASSIFICATION [J].

EDMONDS, JP ;

SCOTT, DL ;

FURST, DE ;

BROOKS, P ;

PAULUS, HE .

ARTHRITIS AND RHEUMATISM, 1993, 36 (03) :336-339

[3] METHOTREXATE IN RESISTANT JUVENILE RHEUMATOID-ARTHRITIS - RESULTS OF THE USA-USSR DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

GIANNINI, EH ;

BREWER, EJ ;

KUZMINA, N ;

SHAIKOV, A ;

MAXIMOV, A ;

VORONTSOV, I ;

FINK, CW ;

NEWMAN, AJ ;

CASSIDY, JT ;

ZEMEL, LS .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (16) :1043-1049

[4]

Hanson V, 1977, Arthritis Rheum, V20, P279

[5]

HAREL L, 1993, ARTHRITIS RHEUM, V36, P137

[6]

LEVINSON JE, 1992, J RHEUMATOL, V19, P6

[7] CARPAL LENGTH IN CHILDREN - USEFUL MEASUREMENT IN DIAGNOSIS OF RHEUMATOID-ARTHRITIS AND SOME CONGENITAL-MALFORMATION SYNDROMES [J].

POZNANSKI, AK ;

HERNANDEZ, RJ ;

GUIRE, KE ;

BEREZA, UL ;

GARN, SM .

RADIOLOGY, 1978, 129 (03) :661-668

[8] EVALUATION OF RESPONSE TO METHOTREXATE BY A FUNCTIONAL INDEX IN JUVENILE CHRONIC ARTHRITIS [J].

RAVELLI, A ;

VIOLA, S ;

RAMENGHI, B ;

DIFUCCIA, G ;

RUPERTO, N ;

ZONTA, L ;

MARTINI, A .

CLINICAL RHEUMATOLOGY, 1995, 14 (03) :322-326

[9] Correlation between conventional disease activity measures in juvenile chronic arthritis [J].

Ravelli, A ;

Viola, S ;

Ruperto, N ;

Corsi, B ;

Ballardini, G ;

Martini, A .

ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (03) :197-200

[10]

RUPERTO N, 1997, J RHEUMATOL, V24, P962