NF-κB in mammary gland development and breast cancer

被引：132

作者：

Cao, YX ^{[1
]}

Karin, M ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2003年 / 8卷 / 02期

关键词：

NF-kappa B; IKK alpha; mammary gland development; cyclin D1; breast cancer;

D O I：

10.1023/A:1025905008934

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nuclear factor of kappaB (NF-kappaB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-kappaB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-kappaB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-kappaB may play an important role in the etiology of breast cancer. Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.

引用

页码：215 / 223

页数：9

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