Trovafloxacin hepatotoxicity

被引：23

作者：

Lazarczyk, DA

Goldstein, NS

Gordon, SC

机构：

[1] William Beaumont Hosp, Div Gastroenterol Hepatol, Royal Oak, MI 48073 USA

[2] Dept Anat Pathol, Royal Oak, MI USA

[3] Wayne State Univ, Sch Med, Detroit, MI USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2001年 / 46卷 / 04期

关键词：

trovafloxacin; toxicity; liver; veno-occlusive disease;

D O I：

10.1023/A:1010741510046

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 19-year-old woman was treated for recurrent sinusitis with oral trovafloxacin and developed acute hepatitis and peripheral eosinophilia, with hepatosplenomegaly and ascites. Laparoscopic liver biopsy showed extensive centrilobular hepatocyte necrosis, likely causing venoocclusive disease-like signs and symptoms. Clinical and laboratory abnormalities resolved completely after prolonged treatment with steroids. The temporal relationship between trovafloxacin and the onset of hepatitis favors this drug as a culprit.

引用

页码：925 / 926

页数：2