Hepcidin and Disorders of Iron Metabolism

被引：373

作者：

Ganz, Tomas ^{[1
,2
]}

Nemeth, Elizabeta ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol, Los Angeles, CA 90095 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 | 2011年 / 62卷

关键词：

anemia; iron overload inflammation; DEFICIENCY ANEMIA; MESSENGER-RNA; FERROPORTIN EXPRESSION; PROTEIN; OVERLOAD; TMPRSS6; URINARY; ERYTHROPHAGOCYTOSIS; QUANTIFICATION; INFLAMMATION;

D O I：

10.1146/annurev-med-050109-142444

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associate with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.

引用

页码：347 / 360

页数：14

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