Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations

被引：203

作者：

Forbes, Lisa R. ^{[1
,2
]}

Vogel, Tiphanie P. ^{[1
,2
]}

Cooper, Megan A. ^{[3
]}

Castro-Wagner, Johana ^{[4
]}

Schussler, Edith ^{[5
,6
,23
]}

Weinacht, Katja G. ^{[7
]}

Plant, Ashley S. ^{[8
]}

Su, Helen C. ^{[9
]}

Allenspach, Eric J. ^{[10
,11
]}

Slatter, Mary ^{[12
,13
]}

Abinun, Mario ^{[12
,13
]}

Lilic, Desa ^{[12
,13
]}

Cunningham-Rundles, Charlotte ^{[5
,6
]}

Eckstein, Olive ^{[14
]}

Olbrich, Peter ^{[15
,16
]}

Guillerman, R. Paul ^{[17
,18
]}

Patel, Niraj C. ^{[19
]}

Demirdag, Yesim Y. ^{[20
]}

Zerbe, Christa ^{[9
]}

Freeman, Alexandra F. ^{[9
]}

Holland, Steven M. ^{[9
]}

Szabolcs, Paul ^{[21
]}

Gennery, Andrew ^{[12
,13
]}

Torgerson, Troy R. ^{[10
,11
]}

Milner, Joshua D. ^{[15
]}

Leiding, Jennifer W. ^{[4
,22
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Div Allergy Immunol & Rheumatol, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Ctr Human Immunobiol, Houston, TX 77030 USA

[3] Washington Univ, Dept Pediat, Div Rheumatol, St Louis, MO 63130 USA

[4] Univ S Florida, Dept Pediat, Div Allergy & Immunol, St Petersburg, FL USA

[5] Icahn Sch Med Mt Sinai, Inst Immunol, Div Allergy & Immunol, New York, NY 10029 USA

[6] Icahn Sch Med Mt Sinai, Inst Immunol, Dept Med & Pediat, New York, NY 10029 USA

[7] Stanford Sch Med, Dept Pediat, Div Stem Cell Transplantat & Regenerat Med, Stanford, CA USA

[8] Childrens Hosp Orange Cty, Dept Pediat Oncol, Orange, CA 92668 USA

[9] NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[10] Univ Washington, Dept Pediat, Div Rheumatol, Seattle, WA 98195 USA

[11] Seattle Childrens Hosp, Seattle, WA USA

[12] Newcastle Upon Tyne Hosp NHS Fdn, Great North Childrens Hosp, Newcastle Upon Tyne, Tyne & Wear, England

[13] Newcastle Upon Tyne Univ, Inst Cellular Med, Primary Immunodeficiency Grp, Newcastle Upon Tyne, Tyne & Wear, England

[14] Texas Childrens Canc Ctr, Dept Hematol & Oncol, Houston, TX USA

[15] NIAID, Lab Allerg Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[16] Univ Hosp Virgen del Rocio, Inst Biomed Seville IBiS, Dept Pediat Infect Dis & Immunopathol, Seville, Spain

[17] Texas Childrens Hosp, Dept Pediat Radiol, Houston, TX 77030 USA

[18] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA

[19] Atrium Hlth, Levine Childrens Hosp, Dept Pediat, Sect Infect Dis & Immunol, Charlotte, NC USA

[20] Columbia Univ, Coll Phys & Surg, New York Presbyterian Morgan Stanley Childrens Ho, Dept Pediat,Div Pediat Allergy & Immunol, New York, NY USA

[21] Univ Pittsburgh, Div Blood & Marrow Transplantat & Cellular Therap, Pittsburgh, PA USA

[22] Johns Hopkins All Childrens Hosp, Canc & Blood Disorders Inst, St Petersburg, FL USA

[23] Weill Cornell Med, Div Pulm Allergy & Immunol, New York, NY USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 142卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RUXOLITINIB;

D O I：

10.1016/j.jaci.2018.07.020

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

[No abstract available]

引用

页码：1665 / 1669

页数：6

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