A biomimetic synthesis of (-)-N(a)-methylervitsine

被引：14

作者：

Bennasar, ML ^{[1
]}

Zulaica, E

Alonso, Y

Mata, I

Molins, E

Bosch, J

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] CSIC, Inst Ciencia Mat, Cerdanyola Del Valles 080193, Spain

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 13期

关键词：

D O I：

10.1039/b102010m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A straightforward, biomimetic synthesis of (-)-N-(a)-methylervitsine involving the nucleophilic addition of the enolate derived from 2-acetylindole 1 to chiral, non-racemic pyridinium salt 2, followed by (Me2N+=CH2) I- induced cyclization of the resultant 1,4-dihydropyridine, with subsequent elaboration of the exocyclic 16-methylene and 20E-ethylidene substituents, is reported.

引用

页码：1166 / 1167

页数：2

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