Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease

被引：56

作者：

Antonini, A ^{[1
]}

De Notaris, R ^{[1
]}

Benti, R ^{[1
]}

De Gaspari, D ^{[1
]}

Pezzoli, G ^{[1
]}

机构：

[1] Ist Clin Perfezionamento, Dept Neurosci, Parkinsons Dis Ctr, Milan, Italy

来源：

NEUROLOGICAL SCIENCES | 2001年 / 22卷 / 01期

关键词：

D O I：

10.1007/s100720170039

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive abnormalities have been reported in a large percentage of patients with Parkinson's disease (PD). Often cognitive changes are sub-clinical and involve frontal lobe function. In other occasions they develop into full dementia. Functional neuroimaging may help characterize these abnormalities. We have studied brain perfusion with SPECT and the tracer ECD in 44 PD patients, 22 presenting with normal cognitive function and 22 with clinical and neuropsychological signs of dementia. Compared with 21 healthy controls, demented PD patients showed significant perfusion decrements in all cortical areas, particularly temporal and parietal regions; in the non-demented cohort reductions were limited to the frontal lobe area. These results suggest that brain perfusion abnormalities are present in PD patients. It is speculated that different pathological mechanisms underlie perfusion differences.

引用

页码：45 / 46

页数：2

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