SYNTHESIS OF 3β-HYDROXY-20-OXO-30-NORLUPAN-28-OIC (PLATANIC) ACID AND ITS GLYCOSIDES

被引：8

作者：

Denisenko, M. V. ^{[1
]}

Samoshina, N. F. ^{[1
]}

Denisenko, V. A. ^{[1
]}

Dmitrenok, P. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Branch, Vladivostok 690022, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 05期

关键词：

betulin; platanic acid; glucosides; PMR; C-13; NMR; BETULINIC ACID; LUPANE-TYPE; TRITERPENOIDS; DERIVATIVES; AGENTS;

D O I：

10.1007/s10600-011-0048-5

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

All available literature data on the chemical synthesis and isolation from natural sources of 3 beta-hydroxy-20-oxo-30-norlupan-28-oic (platanic) acid and its derivatives and their biological activity were reviewed. A one-step synthesis of platanic acid from betulin was developed. Its glycosylation by alpha-acetobromoglucose (ABG) catalyzed by Ag2O in various solvents such as pyridine, CH2Cl2, and their mixture was studied. The optimal synthetic schemes for platanic acid monoglucosides and diglucoside were found. NMR spectra of platanic acid and its glycosides were studied.

引用

页码：741 / 748

页数：8

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