Rat tooth pulp cells elicit neurite growth from trigeminal neurones and express mRNAs for neurotrophic factors in vitro

被引：18

作者：

Lillesaar, C

Eriksson, C

Fried, K

机构：

[1] Linkoping Univ, Fac Hlth Sci, Dept Biomed & Surg, Div Cell Biol, SE-58185 Linkoping, Sweden

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

来源：

NEUROSCIENCE LETTERS | 2001年 / 308卷 / 03期

关键词：

rat; dental pulp; trigeminal ganglion; cell culture; neurotrophic factors; neuritogenesis;

D O I：

10.1016/S0304-3940(01)01997-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Molecular factors control the developmental ingrowth of axons to the tooth pu Ip. Here we examine the ability of pulpal cells to induce neurite outgrowth from neonatal rat trigeminal neurones (TGNs) in vitro. We found that TGNs emitted neurites and formed networks of branches in relation to pulpal cells. Neurones co-cultured with a mixture of pulpal cells and 3T3 fibroblasts formed networks exclusively in relation to the pulpal cells. Cultivated pulpal cells and pulpal tissue produced mRNAs for all neurotrophins and members of the glial cell line-derived neurotrophic factor family. Hence, rat pulpal cells have neuritogenic effects on single TGNs in vitro, that may be associated with secretion of neurotrophic factors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 164

页数：4

共 20 条

[1] The GDNF family ligands and receptors - implications for neural development [J].