Minisci reactions: Versatile CH-functionalizations for medicinal chemists

被引：493

作者：

Duncton, Matthew A. J. ^{[1
]}

机构：

[1] Renovis Inc, San Francisco, CA 94080 USA

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 12期

关键词：

ZENTRALNERVENSYSTEM WIRKENDE SUBSTANZEN; RAY-INDUCED REACTIONS; NUCLEIC-ACID CONSTITUENTS; SULFUR CHLORIDE PENTAFLUORIDE; COMPOSES HETEROAROMATIQUES AZOTES; INTRAMOLECULAR RADICAL ADDITIONS; HORMONE TRH ANALOGS; ANTITUMOR-ACTIVITY; DRUG DISCOVERY; ZUR CHEMIE;

D O I：

10.1039/c1md00134e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.

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收藏

页码：1135 / 1161

页数：27

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