Toward an understanding of the correlates of protective immunity to HIV infection

被引：351

作者：

Haynes, BF

Pantaleo, G

Fauci, AS

机构：

[1] DUKE UNIV, MED CTR,DEPT MED,DIV RHEUMATOL ALLERGY & IMMUNOL, DUKE CTR AIDS RES, DURHAM, NC 27710 USA

[2] NIAID, IMMUNOREGULAT LAB, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1996年 / 271卷 / 5247期

关键词：

D O I：

10.1126/science.271.5247.324

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Considerable progress has been made recently in understanding the genetic, immunologic, and virologic factors in human immunodeficiency virus (HIV)-infected individuals who either rapidly progress or do not progress to acquired immunodeficiency syndrome (AIDS). In addition, detection of HIV-specific immune responses in HIV-negative individuals who have been exposed to the virus multiple times suggests that natural immune responses to HIV may be protective in rare individuals. Understanding the correlates of protective immunity to HIV infection is critical to efforts to develop preventive HIV vaccines as well as to determine the feasibility of treating HIV infection by boosting immunity to HIV.

引用

页码：324 / 328

页数：5

共 194 条

[1] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].