Evaluating on-line solid-phase extraction coupled to liquid chromatography-ion trap mass spectrometry for reliable quantification and confirmation of several classes of antibiotics in urban wastewaters

被引：49

作者：

Feitosa-Felizzola, Juliana ^{[1
]}

Temime, Brice ^{[1
]}

Chiron, Serge ^{[1
]}

机构：

[1] Lab Chim & Environm, F-13331 Marseille 3, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 2007年 / 1164卷 / 1-2期

关键词：

on-line extraction; ion trap; antibiotics; wastewater analysis;

D O I：

10.1016/j.chroma.2007.06.071

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This study provides an evaluation of on-line solid-phase extraction (SPE) and liquid chromatography (LC) in combination with ion trap (IT) mass spectrometry for the simultaneous routine analysis of 12 antibiotics belonging to multiple classes together with carbamazepine and propranolol in sewage treatment effluents. The on-line SPE step warranted high sensitivity and high sample throughput while IT mass detection provided high selectivity for confirmation of positive samples. A single extraction procedure resulted in recoveries ranging from 40% to 120%. Limits of detection were in the 1-46 ng/L range, which constitutes an improvement of a factor of 10 with respect to the off-line SPE procedure. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：95 / 104

页数：10

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