Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats

被引：105

作者：

Iossa, S ^{[1
]}

Lionetti, L ^{[1
]}

Mollica, MP ^{[1
]}

Crescenzo, R ^{[1
]}

Botta, M ^{[1
]}

Barletta, A ^{[1
]}

Liverini, G ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Gen & Environm Physiol, I-80134 Naples, Italy

来源：

BRITISH JOURNAL OF NUTRITION | 2003年 / 90卷 / 05期

关键词：

energy balance; mitochondrial capacity; triiodothyronine; leptin;

D O I：

10.1079/BJN2003000968

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90 d of a.ge). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure. as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that. in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.

引用

页码：953 / 960

页数：8

共 43 条

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