Synthesis of new conformationally rigid paramagnetic α-amino acids

被引：17

作者：

Balog, M

Kálai, T

Jeko, J

Berente, Z

Steinhoff, HJ

Engelhard, M

Hideg, K

机构：

[1] Univ Pecs, Inst Organ & Med Chem, H-7602 Pecs, Hungary

[2] ICN Hungary Ltd, H-4440 Tiszavasvari, Hungary

[3] Univ Pecs, Inst Med Biochem & Chem, H-7602 Pecs, Hungary

[4] Univ Osnabruck, Dept Phys, D-49069 Osnabruck, Germany

[5] Max Planck Inst Mol Physiol, D-44202 Dortmund, Germany

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 51期

关键词：

amino acids; nitroxides; protecting group; TOAC;

D O I：

10.1016/j.tetlet.2003.10.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pyrroline nitroxide based cyclic tetrasubstituted alpha-amino acid and paramagnetic homoproline and their derivatives are described. Introduction of a new paramagnetic protecting group to follow the incorporation of an amino acid into peptides by EPR is also suggested. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9213 / 9217

页数：5

共 37 条

[1]

[Anonymous], 2000, PROTECTING GROUP CHE

[2]

BALASPIRI L, 1979, ACTA PHYS CHEM, V25, P179

[3] First synthesis of a fully active spin-labeled peptide hormone [J].

Barbosa, SR ;

Cilli, EM ;

Lamy-Freund, MT ;

Castrucci, AML ;

Nakaie, CR .

FEBS LETTERS, 1999, 446 (01) :45-48

[4] SITE-SPECIFIC INCORPORATION OF BIOPHYSICAL PROBES INTO PROTEINS [J].

CORNISH, VW ;

BENSON, DR ;

ALTENBACH, CA ;

HIDEG, K ;

HUBBELL, WL ;

SCHULTZ, PG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) :2910-2914

[5] C-60 DERIVATIVE COVALENTLY-LINKED TO A NITROXIDE RADICAL - TIME-RESOLVED EPR EVIDENCE OF ELECTRON-SPIN POLARIZATION BY INTRAMOLECULAR RADICAL-TRIPLET PAIR INTERACTION [J].

CORVAJA, C ;

MAGGINI, M ;

PRATO, M ;

SCORRANO, G ;

VENZIN, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (34) :8857-8858

[6] Unnatural amino acids as probes of protein structure and function [J].

Dougherty, DA .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (06) :645-652

[7] TRIPHOSGENE, A CRYSTALLINE PHOSGENE SUBSTITUTE [J].

ECKERT, H ;

FORSTER, B .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1987, 26 (09) :894-895

[8]

Formaggio F, 2002, CHEM-EUR J, V8, P84, DOI 10.1002/1521-3765(20020104)8:1<84::AID-CHEM84>3.0.CO

[9]

2-N

[10]

GREEN WT, 1991, PROTECTIVE GROUPS OR

← 1 2 3 4 →