Specificity and function of activating Ly-49 receptors

被引:45
作者
Kane, KP [1 ]
Silver, ET [1 ]
Hazes, B [1 ]
机构
[1] Univ Alberta, Dept Med Microbiol & Immunol, Heritage Med Res Ctr 660, Edmonton, AB T6G 2S2, Canada
关键词
D O I
10.1034/j.1600-065X.2001.1810108.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inhibitory Ly-49 receptors allow murine natural killer (NK) cells to kill cells with aberrant class I MHC expression while spa-ring normal cells. This is accomplished by their recognition of specific class I MHC products and prevention of NK-cell lysis of cells that present a normal repertoire of class I MHC ligands - "the missing self hypothesis". However, Ly-49 receptors that lack the cytoplasmic immunoreceptor tyrosine-based inhibitory motifs which is required for inhibition of killing, have also been described. These receptors were-found to stimulate NK killing and are therefore referred to as activating Ly-49 receptors. Interestingly, the activating receptors have class I MHC-binding domains that are nearly indistinguishable from those of the inhibiting receptors, and binding to class I MHC has now been demonstrated for three activating receptors. Presently, there is no defined physiological role for activating Ly-49 receptors. Here we present an overview of current knowledge regarding the diversity, structure and function of activating Ly-49 receptors with a focus on class I MHC specificity, and we discuss their potential role(s) in natural resistance.
引用
收藏
页码:104 / 114
页数:11
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