Molecular characterization of resistance to mupirocin in methicillin-susceptible and -resistant isolates of Staphylococcus aureus from nasal samples

被引:31
作者
Chaves, F [1 ]
García-Martínez, J [1 ]
de Miguel, S [1 ]
Otero, JR [1 ]
机构
[1] Hosp Univ Doce Octubre, Serv Microbiol, Madrid 28041, Spain
关键词
D O I
10.1128/JCM.42.2.822-824.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A total of 15 of 101 (14.8%) nasal methicillin-resistant Staphylococcus aureus (MRSA) isolates exhibited mupirocin resistance (Mup(r)) compared with 1 of 154 (0.6%) methicillin-susceptible Staphylococcus aureus isolates. A total of 14 (93%) isolates exhibiting high-level Mup(r) belonged to a single clone. Horizontal plasmid transfer and transmission of Mup(r) strains contribute to a high incidence of Mup(r) MRSA at our institution.
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收藏
页码:822 / 824
页数:3
相关论文
共 19 条
[1]   Use of the polymerase chain reaction for rapid detection of high-level mupirocin resistance in staphylococci [J].
Anthony, RM ;
Conner, AM ;
Power, EGM ;
French, GL .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1999, 18 (01) :30-34
[2]  
Boyce JM, 1996, INFECT CONT HOSP EP, V17, P775
[3]   The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice [J].
Cookson, BD .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 41 (01) :11-18
[4]   SPREAD AND MAINTENANCE OF A DOMINANT METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS (MRSA) CLONE DURING AN OUTBREAK OF MRSA DISEASE IN A SPANISH HOSPITAL [J].
DOMINGUEZ, MA ;
DELENCASTRE, H ;
LINARES, J ;
TOMASZ, A .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (09) :2081-2087
[5]   INTERPRETIVE CRITERIA FOR DISK DIFFUSION SUSCEPTIBILITY TESTING OF MUPIROCIN, A TOPICAL ANTIBIOTIC [J].
FUCHS, PC ;
JONES, RN ;
BARRY, AL .
JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (03) :608-609
[6]   MULTIPLEX PCR FOR IDENTIFICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCI IN THE CLINICAL LABORATORY [J].
GEHA, DJ ;
UHL, JR ;
GUSTAFERRO, CA ;
PERSING, DH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (07) :1768-1772
[7]   Reduction of Staphylococcus aureus nasal carriage and infection in dialysis patients [J].
Herwaldt, LA .
JOURNAL OF HOSPITAL INFECTION, 1998, 40 :S13-S23
[8]   Surgical site infections in orthopedic surgery: The effect of mupirocin nasal ointment in a double-blind, randomized, placebo-controlled study [J].
Kalmeijer, MD ;
Coertjens, H ;
van Nieuwland-Bollen, PM ;
Bogaers-Hofman, D ;
de Baere, GAJ ;
Stuurman, A ;
van Belkum, A ;
Kluytmans, JAJW .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (04) :353-358
[9]   Nasal carriage of Staphylococcus aureus: Epidemiology, underlying mechanisms, and associated risks [J].
Kluytmans, J ;
vanBelkum, A ;
Verbrugh, H .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (03) :505-+
[10]  
Leski TA, 1999, J CLIN MICROBIOL, V37, P2781