Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE

被引：92

作者：

Zheng, QH ^{[1
]}

Mock, BH ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

来源：

BIOMEDICAL CHROMATOGRAPHY | 2005年 / 19卷 / 09期

关键词：

positron emission tomography; carbon-11; radiotracer; HPLC; SPE;

D O I：

10.1002/bmc.494

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used rachopharmaceuticals such as [C-11]raclopride, [C-11]beta-CFT and [C-11]choline from their unlabeled precursors. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：671 / 676

页数：6

共 12 条

[1]

Brashear A, 1999, MOVEMENT DISORD, V14, P132, DOI 10.1002/1531-8257(199901)14:1<132::AID-MDS1022>3.0.CO

[2]

2-J

[3] An improved synthesis of PET dopamine D2 receptors radioligand [11C]raclopride [J].

Fei, XS ;

Mock, BH ;

DeGrado, TR ;

Wang, JQ ;

Glick-Wilson, BE ;

Sullivan, ML ;

Hutchins, GD ;

Zheng, QH .

SYNTHETIC COMMUNICATIONS, 2004, 34 (10) :1897-1907

[4]

Fowler JS, 1999, J NUCL MED, V40, P1154

[5]

Hara T, 1998, J NUCL MED, V39, P990

[6]

JEWETT DM, 1992, APPL RADIAT ISOTOPES, V43, P1383

[7] Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate [J].

Mock, BH ;

Mulholland, GK ;

Vavrek, MT .

NUCLEAR MEDICINE AND BIOLOGY, 1999, 26 (04) :467-471

[8]

MULHOLLAND KM, 1999, J LABELLED CPD RA S1, V42, pS459

[9] Molecular imaging [J].

Weissleder, R ;

Mahmood, U .

RADIOLOGY, 2001, 219 (02) :316-333

[10] [11C]Choline as a PET biomarker for assessment of prostate cancer tumor models [J].

Zheng, QH ;

Gardner, TA ;

Raikwar, S ;

Kao, CH ;

Stone, KL ;

Martinez, TD ;

Mock, BH ;

Fei, XS ;

Wang, JQ ;

Hutchins, GD .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (11) :2887-2893

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