Flavonoids and the inhibition of PKC and PI 3-kinase

被引：204

作者：

Gamet-Payrastre, L

Manenti, S

Gratacap, MP

Tulliez, J

Chap, H

Payrastre, B

机构：

[1] INRA, Lab Xenobiot, F-31931 Toulouse 9, France

[2] CHU Purpan, Inst Federat Rech 30, INSERM, CJF 95 10, Toulouse, France

[3] CHU Purpan, Inst Federat Rech 30, INSERM, U326, Toulouse, France

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1999年 / 32卷 / 03期

关键词：

D O I：

10.1016/S0306-3623(98)00220-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Flavonoids provide a large number of interesting natural compounds that are consumed daily and exhibit more or less potent and selective effects on some signaling enzymes as well as on the growth and proliferation of certain malignant cells in vitro. Among the identified signal transducers, phosphoinositide 3-kinase (PI 3-kinase) and protein kinase C (PKC) are now considered key players in many cellular responses including cell multiplication, apoptosis, and transformation. Despite their lack of strict specificity, some flavonoids provide valuable bases for the design of analogues that could be used to specifically block particular isoforms of PI 3-kinase or PKC and their downstream-dependent cellular responses. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：279 / 286

页数：8

共 52 条

[1] CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION [J].