Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

被引：111

作者：

Eltboli, Osama ^{[1
,2
]}

Mistry, Vijay ^{[1
]}

Barker, Bethan ^{[1
]}

Brightling, Chris E. ^{[1
]}

机构：

[1] Univ Leicester, Dept Infect Immun & Inflammat, Inst Lung Hlth, Leicester LE3 9QP, Leics, England

[2] Benghazi Univ, Fac Med, Dept Med, Benghazi, Libya

来源：

RESPIROLOGY | 2015年 / 20卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

blood eosinophil; chronic obstructive pulmonary disease; remodelling; reticular basement membrane; submucosal eosinophil; PLACEBO-CONTROLLED TRIAL; SPUTUM EOSINOPHILIA; DOUBLE-BLIND; EXACERBATIONS; ASTHMA;

D O I：

10.1111/resp.12475

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

A sputum eosinophilia is observed in 10-40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.

引用

页码：667 / 670

页数：4

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