Conservation of dorsal-ventral patterning in arthropods and chordates

被引：92

作者：

Ferguson, EL

机构：

[1] Dept. of Molec. Genet./Cell Biology, University of Chicago, Chicago, IL 60637

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(96)80063-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.

引用

页码：424 / 431

页数：8

共 73 条

[1]

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