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Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

被引：11
作者：
Jiang, RL
Norton, CR
Copeland, NG
Gilbert, DJ
Jenkins, NA
Gridley, T
机构：
[1] Jackson Lab, Bar Harbor, ME 04609 USA
[2] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab, Frederick, MD 21702 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1443卷 / 1-2期
关键词：
mouse slug (Slugh) gene; genomic organization; genomic expression; chromosomal localization;
D O I：
10.1016/S0167-4781(98)00225-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis, The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16. (C) 1998 Elsevier Science B.V. All rights reserved.
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收藏
页码：251 / 254
页数：4
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