Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors

被引：57

作者：

Gantz, I

Konda, Y

Yang, YK

Miller, DE

Dierick, HA

Yamada, T

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,MED CTR,DEPT PEDIAT,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,MED CTR,DEPT PHYSIOL,ANN ARBOR,MI 48109

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 74卷 / 04期

关键词：

D O I：

10.1159/000134436

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report the cloning of a novel human gene, CMKLR1, which encodes a protein that has notable sequence and structural homology to the seven transmembrane G-protein linked chemokine receptors. This gene has 55% nucleotide sequence homology to the IL-8 type I receptor and 53% to the N-formyl peptide related receptor 1 genes. The mRNA of this receptor is expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow, and fetal liver. Using fluorescence in situ hybridization the gene encoding CMLKR1 (chemokine-like receptor 1) was localized to human chromosome 12q24.1.

引用

页码：286 / 290

页数：5

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