Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes

被引：82

作者：

Osawa, H ^{[1
]}

Onuma, H

Ochi, M

Murakami, A

Yamauchi, J

Takasuka, T

Tanabe, F

Shimizu, I

Kato, K

Nishida, W

Yamada, K

Tabara, Y

Yasukawa, M

Fujii, Y

Ohashi, J

Miki, T

Makino, H

机构：

[1] Ehime Univ, Sch Med, Dept Lab Med, Ehime 7910295, Japan

[2] Univ Fukui, Fac Med Sci, Dept Biochem, Fukui, Japan

[3] Ehime Univ, Sch Med, Dept Med Gen, Matsuyama, Ehime 790, Japan

[4] Ehime Univ, Sch Med, Dept Internal Med 1, Matsuyama, Ehime 790, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Human Genet, Sch Int Hlth, Tokyo, Japan

[6] Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 335卷 / 02期

关键词：

resistin; insulin resistance; SNP; polymorphism; promoter; mRNA; monocyte; adipocyte; type; 2; diabetes; serum level;

D O I：

10.1016/j.bbrc.2005.07.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source in humans remain unknown. The G/G genotype of resistin single nucleotide polymorphism, SNP-420, induces type 2 diabetes mellitus (T2DM) by increasing promoter activity. We elucidated factors correlated with serum resistin and effects of SNP-420 on monocyte resistin mRNA. In 198 T2DM and 157 controls, fasting serum resistin was higher in T2DM. Multiple regression analysis revealed that SNP-420 genotype was the strongest determinant of serum resistin. In T2DM, 1-year duration of T2DM and 1% HbAlc was also correlated with 0.19 and 0.54 ng/ml serum resistin, respectively. Logistic regression analysis revealed that serum resistin was an independent factor for T2DM. In 23 healthy volunteers, monocyte resistin mRNA was positively correlated with its simultaneous serum levels and was higher in G/G genotype. Thus, SNP-420 determines monocyte rnRNA and serum levels of resistin, which could induce T2DM. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：596 / 602

页数：7

共 43 条

[1] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].

Altshuler, D ;

Hirschhorn, JN ;

Klannemark, M ;

Lindgren, CM ;

Vohl, MC ;

Nemesh, J ;

Lane, CR ;

Schaffner, SF ;

Bolk, S ;

Brewer, C ;

Tuomi, T ;

Gaudet, D ;

Hudson, TJ ;

Daly, M ;

Groop, L ;

Lander, ES .

NATURE GENETICS, 2000, 26 (01) :76-80

[2] Novel resistin promoter polymorphisms: Association with serum resistin level in Japanese obese individuals [J].

Azuma, K ;

Oguchi, S ;

Matsubara, Y ;

Mamizuka, T ;

Murata, M ;

Kikuchi, H ;

Watanabe, K ;

Katsukawa, F ;

Yamazaki, H ;

Shimada, A ;

Saruta, T .

HORMONE AND METABOLIC RESEARCH, 2004, 36 (08) :564-570

[3] Correlation between serum resistin level and adiposity in obese individuals [J].

Azuma, K ;

Katsukawa, F ;

Oguchi, S ;

Murata, M ;

Yamazaki, H ;

Shimada, A ;

Saruta, T .

OBESITY RESEARCH, 2003, 11 (08) :997-1001

[4] Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[5] Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans [J].

Cho, YM ;

Youn, BS ;

Chung, SS ;

Kim, KW ;

Lee, HK ;

Yu, KY ;

Park, HJ ;

Shin, HD ;

Park, KS .

DIABETOLOGIA, 2004, 47 (03) :559-565

[6] PATHOGENESIS OF NIDDM - A BALANCED OVERVIEW [J].

DEFRONZO, RA ;

BONADONNA, RC ;

FERRANNINI, E .

DIABETES CARE, 1992, 15 (03) :318-368

[7] 5′ flanking variants of resistin are associated with obesity [J].

Engert, JC ;

Vohl, MC ;

Williams, SM ;

Lepage, P ;

Loredo-Osti, JC ;

Faith, J ;

Doré, C ;

Renaud, Y ;

Burtt, NP ;

Villeneuve, A ;

Hirschhorn, JN ;

Altshuler, D ;

Groop, LC ;

Després, JP ;

Gaudet, D ;

Hudson, TJ .

DIABETES, 2002, 51 (05) :1629-1634

[8] Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes [J].

Fujinami, A ;

Obayashi, H ;

Ohta, K ;

Ichimura, T ;

Nishimura, M ;

Matsui, H ;

Kawahara, Y ;

Yamazaki, M ;

Ogata, M ;

Hasegawa, G ;

Nakamura, N ;

Yoshikawa, T ;

Nakano, K ;

Ohta, M .

CLINICA CHIMICA ACTA, 2004, 339 (1-2) :57-63

[9]

Gavin JR, 1999, DIABETES CARE, V22, pS5

[10] Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [J].

Hara, K ;

Boutin, P ;

Mori, Y ;

Tobe, K ;

Dina, C ;

Yasuda, K ;

Yamauchi, T ;

Otabe, S ;

Okada, T ;

Eto, K ;

Kadowaki, H ;

Hagura, R ;

Akanuma, Y ;

Yazaki, Y ;

Nagai, R ;

Taniyama, M ;

Matsubara, K ;

Yoda, M ;

Nakano, Y ;

Kimura, S ;

Tomita, M ;

Kimura, S ;

Ito, C ;

Froguel, P ;

Kadowaki, T .

DIABETES, 2002, 51 (02) :536-540

← 1 2 3 4 5 →