Heart and coronary artery protection in patients with mediastinal Hodgkin lymphoma treated with intensity-modulated radiotherapy: Dose constraints to virtual volumes or to organs at risk?

被引：21

作者：

Ghalibafian, Mithra ^{[1
]}

Beaudre, Anne ^{[2
]}

Girinsky, Theodore ^{[1
]}

机构：

[1] Inst Gustave Roussy, Dept Radiat Oncol, F-94805 Villejuif, France

[2] Inst Gustave Roussy, Dept Med Phys, F-94805 Villejuif, France

来源：

RADIOTHERAPY AND ONCOLOGY | 2008年 / 87卷 / 01期

关键词：

Hodgkin lymphoma; mediastinal masses; intensity-modulated radiotherapy; virtual volumes;

D O I：

10.1016/j.radonc.2007.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: To increase heart and coronary artery protection in patients with mediastinal Hodgkin lymphoma treated with intensity-modulated radiotherapy (IMRT). Materials and methods: Twenty patients with early-stage mediastinal Hodgkin lymphoma entered the study. IMRT was delivered to the initially involved lymph node volumes. Various virtual volumes (VVs) were designed to improve the protection of the heart and the origin of the coronary arteries, which were the organs at risk (OARs), while preserving adequate PTV coverage. The results obtained with VVs were then compared with those obtained with dose constraints assigned to OARS. Results: The most satisfactory VV was obtained using the PTV expansion concept. The best compromise between adequate PTV coverage and OAR protection was obtained with dose constraints assigned to the PTV expansion VV and to the origin of the coronary arteries. Conclusions: IMRT can be improved by using dose constraints assigned to the PTV expansion VV and/or to the origin of the coronary arteries. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：82 / 88

页数：7

共 15 条

[1] Long-term cause-specific mortality of patients treated for Hodgkin's disease [J].

Aleman, BMP ;

van den Belt-Dusebout, AW ;

Klokman, WJ ;

van't Veer, MB ;

Bartelink, H ;

van Leeuwen, FE .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (18) :3431-3439

[2]

[Anonymous], 1993, 50 ICRU

[3] Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin's disease [J].

Constine, LS ;

Schwartz, RG ;

Savage, DE ;

King, V ;

Muhs, A .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1997, 39 (04) :897-906

[4]

Diehl V, 2005, J CLIN ONCOL, V23, p561S

[5] Improvement of treatment plans developed with intensity-modulated radiation therapy for concave-shaped head and neck tumors [J].

Dogan, N ;

Leybovich, LB ;

King, S ;

Sethi, A ;

Emami, B .

RADIOLOGY, 2002, 223 (01) :57-64

[6]

Esik O., 1997, Strahlentherapie und Onkologie, V173, P193

[7] Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes? [J].

Girinsky, T ;

Pichenot, C ;

Beaudre, A ;

Ghalibafian, M ;

Lefkopoulos, D .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 64 (01) :218-226

[8] Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: Concepts and guidelines [J].

Girinsky, Theodore ;

van der Maazen, Richard ;

Specht, Lena ;

Aleman, Berthe ;

Poortmans, Philip ;

Lievens, Yolande ;

Meijnders, Paul ;

Ghalibafian, Mithra ;

Meerwaldt, Jacobus ;

Noordijk, Evert .

RADIOTHERAPY AND ONCOLOGY, 2006, 79 (03) :270-277

[9] Intensity-modulated radiotherapy for lymphoma involving the mediastinum [J].

Goodman, KA ;

Toner, S ;

Hunt, M ;

Wu, EJ ;

Yahalom, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 62 (01) :198-206

[10] FACTORS AFFECTING LATE MORTALITY FROM HEART-DISEASE AFTER TREATMENT OF HODGKINS-DISEASE [J].

HANCOCK, SL ;

TUCKER, MA ;

HOPPE, RT .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (16) :1949-1955

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