The ER in 3D: a multifunctional dynamic membrane network

被引：223

作者：

Friedman, Jonathan R. ^{[1
]}

Voeltz, Gia K. ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 12期

关键词：

ENDOPLASMIC-RETICULUM; NUCLEAR-ENVELOPE; HOMOTYPIC FUSION; BINDING-PROTEIN; LIPID-TRANSFER; CONTACTS; CELLS; MITOCHONDRIA; ORGANIZATION; SITES;

D O I：

10.1016/j.tcb.2011.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions.

引用

页码：709 / 717

页数：9

共 73 条

[1] Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation [J].

Anderson, Daniel J. ;

Hetzer, Martin W. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (05) :911-924

[2] Endoplasmic reticulum of animal cells and its organization into structural and functional domains [J].

Baumann, O ;

Walz, B .

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 205, 2001, 205 :149-214

[3] Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response [J].

Bernales, Sebastian ;

McDonald, Kent L. ;

Walter, Peter .

PLOS BIOLOGY, 2006, 4 (12) :2311-2324

[4] Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes [J].

Bian, Xin ;

Klemm, Robin W. ;

Liu, Tina Y. ;

Zhang, Miao ;

Sun, Sha ;

Sui, Xuewu ;

Liu, Xinqi ;

Rapoport, Tom A. ;

Hu, Junjie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (10) :3976-3981

[5] How and why does the endoplasmic reticulum move? [J].

Bola, Becky ;

Allan, Viki .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 :961-965

[6] Mitochondria on the move [J].

Boldogh, Istvan R. ;

Pon, Liza A. .

TRENDS IN CELL BIOLOGY, 2007, 17 (10) :502-510

[7] Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane [J].

Cooney, JR ;

Hurlburt, JL ;

Selig, DK ;

Harris, KM ;

Fiala, JC .

JOURNAL OF NEUROSCIENCE, 2002, 22 (06) :2215-2224

[8] Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface [J].

Csordas, Gyoergy ;

Varnai, Peter ;

Golenar, Tuende ;

Roy, Swati ;

Purkins, George ;

Schneider, Timothy G. ;

Balla, Tamas ;

Hajnoczky, Gyorgy .

MOLECULAR CELL, 2010, 39 (01) :121-132

[9] Structural and functional features and significance of the physical linkage between ER and mitochondria [J].

Csordas, Gyorgy ;

Renken, Christian ;

Varnai, Peter ;

Walter, Ludivine ;

Weaver, David ;

Buttle, Karolyn F. ;

Balla, Tamas ;

Mannella, Carmen A. ;

Hajnoczky, Gyorgy .

JOURNAL OF CELL BIOLOGY, 2006, 174 (07) :915-921

[10] Mitofusin 2 tethers endoplasmic reticulum to mitochondria [J].

de Brito, Olga Martins ;

Scorrano, Luca .

NATURE, 2008, 456 (7222) :605-U47

← 1 2 3 4 5 6 7 8 →