Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

被引：142

作者：

Dobrowolski, Radek ^{[1
,2
]}

De Robertis, Edward M. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

TYROSINE PHOSPHORYLATION; RECEPTOR INTERNALIZATION; EARLY ENDOSOMES; BETA-CATENIN; PROTEIN; LRP6; PATHWAY; COMPLEX; NOTCH; HRS;

D O I：

10.1038/nrm3244

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targeting receptors for degradation in lysosomes, but it can also maintain signals in early signalling endosomes. In both cases, localization to multivesicular endosomes en route to lysosomes is thought to terminate signalling. However, during WNT signal transduction, sequestration of the enzyme glycogen synthase kinase 3 (GSK3) inside multivesicular endosomes results in the stabilization of many cytosolic proteins. Thus, the role of endocytosis during signal transduction may be more diverse than anticipated, and multivesicular endosomes may constitute a crucial signalling organelle.

引用

页码：53 / 60

页数：8

共 85 条

[1] Src-mediated tyrosine phosphorylation of dynamin is required for β2-adrenergic receptor internalization and mitogen-activated protein kinase signaling [J].