Investigating Influenza A Virus Infection: Tools To Track Infection and Limit Tropism

被引：26

作者：

Fiege, Jessica K.

Langlois, Ryan A. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Microbiol & Immunol, Minneapolis, MN 55455 USA

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 12期

关键词：

IN-VIVO; REPORTER VIRUS; TRANSMISSION; REPLICATION; DYNAMICS; STRATEGY; VACCINES; MICE;

D O I：

10.1128/JVI.00462-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A viruses display a broad cellular tropism within the respiratory tracts of mammalian hosts. Uncovering the relationship between tropism and virus immunity, pathogenesis, and transmission will be critical for the development of therapeutic interventions. Here we discuss recent developments of several recombinant strains of influenza A virus. These viruses have inserted reporters to track tropism, microRNA target sites to restrict tropism, or barcodes to assess transmission dynamics, expanding our understanding of pathogen-host interactions.

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收藏

页码：6167 / 6170

页数：4

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