Major uropathogenic Escherichia coli strain isolated in the northwest of England identified by multilocus sequence typing

被引：147

作者：

Lau, Siu Ha ^{[1
,3
]}

Reddy, Suganya ^{[2
]}

Cheesbrough, John ^{[2
]}

Bolton, Frederick J. ^{[3
]}

Willshaw, Geraldine ^{[4
]}

Cheasty, Tom ^{[4
]}

Fox, Andrew J. ^{[3
]}

Upton, Mathew ^{[1
]}

机构：

[1] Univ Manchester, Sch Med, Dept Med Microbiol, Manchester Royal Infirm, Manchester M13 9WL, Lancs, England

[2] Lancashire Teaching Hosp NHS Fdn Trust, Royal Preston Hosp, Preston Microbiol Serv, Preston PR2 9HT, Lancs, England

[3] Manchester Royal Infirm, Hlth Protect Agcy NW Lab, Manchester M13 9WZ, Lancs, England

[4] Ctr Infect, Lab Enter Pathogens, Escherichia Shigella Yersinia & Vibrio Reference, London NW9 5HT, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 03期

关键词：

D O I：

10.1128/JCM.02065-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.

引用

页码：1076 / 1080

页数：5

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