Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure

被引：43

作者：

Erdely, Aaron ^{[1
]}

Liston, Angie ^{[1
]}

Salmen-Muniz, Rebecca ^{[1
]}

Hulderman, Tracy ^{[1
]}

Young, Shih-Houng ^{[2
]}

Zeidler-Erdely, Patti C. ^{[2
,3
]}

Castranova, Vincent ^{[2
,3
]}

Simeonova, Petia P. ^{[1
]}

机构：

[1] NIOSH, TMBB, HELD, Morgantown, WV 26505 USA

[2] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA

[3] NIOSH, Lab Occupat Cardiovasc Toxicol, Hlth Effects Lab Div, Morgantown, WV 26505 USA

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2011年 / 53卷 / 06期

关键词：

CARDIOVASCULAR RISK-FACTORS; APOLIPOPROTEIN-A-I; AIR-POLLUTION; MATRIX METALLOPROTEINASES; COMPLEMENT ACTIVATION; LUNG INFLAMMATION; TRANSITION-METALS; DYSFUNCTION; COAGULATION; INHIBITOR;

D O I：

10.1097/JOM.0b013e31821ad724

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Objective: Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure. Methods: Mice were exposed by pharyngeal aspiration to 40-mu g CNT and harvested 24 hours, 7 days, and 28 days postexposure for measurements of whole blood, lung and extrapulmonary tissue gene expression, blood and bronchoalveolar lavage (BAL) differentials, and serum protein profiling. Results: Early effects included increased inflammatory blood gene expression and serum cytokines followed by an acute phase response (eg, CRP, SAA-1, SAP). Beyond 24 hours, there was a consistent increase in blood and BAL eosinophils. At 28 day, serum acute phase proteins with immune function including complement C3, apolipoproteins A-I and A-II, and alpha(2)-macroglobulin were increased. Conclusions: Carbon nanotube exposure resulted in measurable systemic markers but lacked specificity to distinguish from other pulmonary exposures.

引用

页码：S80 / S86

页数：7

共 68 条

[1]

[Anonymous], ENV HLTH PERSPECT

[2]

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress [J].