Do stem cells exist in the adult kidney?

被引:33
作者
Gupta, Sandeep [1 ]
Rosenberg, Mark E.
机构
[1] Univ Minnesota, Dept Med, Div Kidney Dis & Hypertens, Minneapolis, MN 55455 USA
关键词
acute renal failure; oct-4 stem cell marker; progenitor cells; sca-1 stem cell marker; stem cells; regeneration;
D O I
10.1159/000117311
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Adult stem cells exist in many organs and play a critical role in normal cell turnover and the response to injury. The existence of adult stem cells in the mammalian kidney remains controversial. Kidney stem cells have been isolated and characterized by many groups, often with discrepant results. This article will review the current state of knowledge regarding adult kidney stem cells and discuss future directions for kidney stem cell research. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:607 / 613
页数:7
相关论文
共 81 条
[1]
An introduction to stem cells [J].
Alison, MR ;
Poulsom, R ;
Forbes, S ;
Wright, NA .
JOURNAL OF PATHOLOGY, 2002, 197 (04) :419-423
[2]
Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood [J].
Baal, N ;
Reisinger, K ;
Jahr, H ;
Bohle, RM ;
Liang, O ;
Münstedt, K ;
Rao, CV ;
Preissner, KT ;
Zygmunt, MT .
THROMBOSIS AND HAEMOSTASIS, 2004, 92 (04) :767-775
[3]
MOLECULAR EVENTS IN THE ORGANIZATION OF RENAL TUBULAR EPITHELIUM - FROM NEPHROGENESIS TO REGENERATION [J].
BACALLAO, R ;
FINE, LG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06) :F913-F924
[4]
Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure [J].
Basile, DP ;
Fredrich, K ;
Alausa, M ;
Vio, CP ;
Liang, MY ;
Rieder, MR ;
Greene, AS ;
Cowley, AW .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (05) :F953-F963
[5]
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure [J].
Bonventre, JV .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (06) :S55-S61
[6]
Isolation of renal progenitor cells from adult human kidney [J].
Bussolati, B ;
Bruno, S ;
Grange, C ;
Buttiglieri, S ;
Deregibus, MC ;
Cantino, D ;
Camussi, G .
AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (02) :545-555
[7]
A side order of stem cells: The SP phenotype [J].
Challen, GA ;
Little, MH .
STEM CELLS, 2006, 24 (01) :3-12
[8]
Identifying the molecular phenotype of renal progenitor cells [J].
Challen, GA ;
Martinez, G ;
Davis, MJ ;
Taylor, DF ;
Crowe, M ;
Teasdale, RD ;
Grimmond, SM ;
Little, MH .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (09) :2344-2357
[9]
Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity [J].
Challen, Grant A. ;
Bertoncello, Ivan ;
Deane, James A. ;
Ricardo, Sharon D. ;
Little, Melissa H. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (07) :1896-1912
[10]
Independent association between acute renal failure and mortality following cardiac surgery [J].
Chertow, GM ;
Levy, EM ;
Hammermeister, KE ;
Grover, F ;
Daley, J .
AMERICAN JOURNAL OF MEDICINE, 1998, 104 (04) :343-348