Cytoprotective channels in mitochondria

被引：10

作者：

Ardehali, H ^{[1
]}

机构：

[1] Northwestern Univ, Cardiovasc Inst, Chicago, IL 60611 USA

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 2005年 / 37卷 / 03期

关键词：

mitochondria; ischemic preconditioning; mitochondrial ATP-sensitive potassium channel; uncoupling proteins; Ca2+ stop-activated K+ stop channel; apoptosis; ion channels;

D O I：

10.1007/s10863-005-6582-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Several ion channels are expressed in the inner and outer membranes of mitochondria, but the exact function of these channels is not completely understood. The opening of certain channels is thought to induce the process of cell death or apoptosis. However, other channels of the inner mitochondrial membrane help protect against ischemic injury and oxidative stress. Mitochondrial ATP-sensitive K+ channels (mitoK(ATP)) and mitochondrial Ca2+-activated K+ channels (mitoK(Ca)) are the primary protective channels that have been identified. In addition to their thermogenic role, certain isoforms of uncoupling proteins are also shown to have protective roles in certain experimental models. This review attempts to provide an updated overview of the proposed mechanism for the protective function of these membrane proteins. Controversies and unanswered questions regarding these channels will also be discussed.

引用

页码：171 / 177

页数：7

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