Urocortin: A beneficial or detrimental agent to endothelium?

被引：13

作者：

Yang, Cui ^{[1
]}

Xu, Yinyan ^{[1
]}

Li, Shengnan ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Cardiovasc Pharmacol, Nanjing 210029, Jiangsu, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 371卷 / 03期

关键词：

urocortin; corticotropin-releasing factor; endothelium; endothelial dysfunction;

D O I：

10.1016/j.bbrc.2008.01.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a member of the corticotropin-releasing factor (CRF) family, urocortin (UCN) has been demonstrated to show diverse effects on cardiovascular system. It is commonly considered as a protective agent on vascular function. However, a growing body of evidence suggests that some effects of UCN may lead to endothelial dysfunction (ED) which may be the cause or consequence of vascular disease and a hallmark of known cardiovascular risk factors. The present review is then focused on recent evidence that reveals the beneficial and detrimental effects of UCN on endothelium. (C) 2008 Published by Elsevier Inc.

引用

页码：345 / 349

页数：5

共 46 条

[1] Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization [J].

Bale, TL ;

Giordano, FJ ;

Hickey, RP ;

Huang, Y ;

Nath, AK ;

Peterson, KL ;

Vale, WW ;

Lee, KF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (11) :7734-7739

[2] Human lymphocytes produce urocortin, but not corticotropin-releasing hormone [J].

Bamberger, CM ;

Wald, M ;

Bamberger, AM ;

Ergün, S ;

Beil, FU ;

Schulte, HM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (02) :708-711

[3] Endothelial function: From vascular biology to clinical applications [J].

Behrendt, D ;

Ganz, P .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (10C) :40L-48L

[4] CRH-like peptides protect cardiac myocytes from lethal ischaemic injury [J].

Brar, BK ;

Stephanou, A ;

Okosi, A ;

Lawrence, KM ;

Knight, RA ;

Marber, MS ;

Latchman, DS .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1999, 158 (1-2) :55-63

[5] Endothelium-derived hyperpolarizing factor - A cousin to nitric oxide and prostacyclin [J].

Bryan, RM ;

You, JP ;

Golding, EM ;

Marrelli, SP .

ANESTHESIOLOGY, 2005, 102 (06) :1261-1277

[6] Mechanisms underlying the ani-inflammatory actions of central corticotropin-releasing factor [J].

Casadevall, M ;

Saperas, E ;

Panés, J ;

Salas, A ;

Anderson, DC ;

Malagelada, JR ;

Piqué, JM .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1999, 276 (04) :G1016-G1026

[7] The dual personality of NO [J].

Colasanti, M ;

Suzuki, H .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (07) :249-252

[8] NITRIC-OXIDE FUNCTIONS AS AN INHIBITOR OF PLATELET-ADHESION UNDER FLOW CONDITIONS [J].

DEGRAAF, JC ;

BANGA, JD ;

MONCADA, S ;

PALMER, RMJ ;

DEGROOT, PG ;

SIXMA, JJ .

CIRCULATION, 1992, 85 (06) :2284-2290

[9] Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells [J].

Esposito, P ;

Basu, S ;

Letourneau, R ;

Jacobson, S ;

Theoharides, TC .

BRAIN RESEARCH, 2003, 968 (02) :192-198

[10] Modulation of endothelial prostaglandin synthesis by corticotropin releasing factor and antagonists [J].

Fleisher-Berkovich, S ;

Rimon, G ;

Danon, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 353 (2-3) :297-302

← 1 2 3 4 5 →