A convenient and highly regio and stereoselective method for the synthesis of (E)-3-alkylidene isobenzofuran-1(3H)-ones (phthalides)

被引：27

作者：

Mukhopadhyay, R ^{[1
]}

Kundu, NG ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Organ Chem, Kolkata 700032, W Bengal, India

来源：

TETRAHEDRON | 2001年 / 57卷 / 46期

关键词：

alkynes; isobenzofuran-1(3H)ones; palladium catalysis;

D O I：

10.1016/S0040-4020(01)00943-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Iodobenzyl alcohol on treatment with acetylenic carbinols in the presence of a palladium catalyst and copper(I) iodide as a cocatalyst afforded disubstituted alkynes. Jones oxidation of the disubstituted alkynes led to (E)-3-alkylidene isobenzofuran-1(3H)-ones in good yields in a highly regio and stereoselective manner. The E-isomers were obtained exclusively instead of the more stable Z-isomers. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9475 / 9480

页数：6

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