CSF amyloid β42 and tau levels correlate with AIDS dementia complex

被引：140

作者：

Brew, BJ

Pemberton, L

Blennow, K

Wallin, A

Hagberg, L

机构：

[1] Univ New S Wales, St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia

[2] Univ New S Wales, St Vincents Hosp, Det HIV Med, Darlinghurst, NSW 2010, Australia

[3] Univ New S Wales, St Vincents Hosp, Ctr Immunol, Darlinghurst, NSW 2010, Australia

[4] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Clin Neurosci, Molndal, Sweden

[5] Univ Gothenburg, Sahlgrens Univ Hosp, Dept Infect Dis, Gothenburg, Sweden

来源：

NEUROLOGY | 2005年 / 65卷 / 09期

关键词：

D O I：

10.1212/01.wnl.0000183293.95787.b7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid((1-42)) (A beta 42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF A beta 42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.

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页码：1490 / 1492

页数：3

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