Recognition of telomeric DNA

被引：67

作者：

Konig, P

Rhodes, D

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(97)01008-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-dimensional structure of the yeast telomere-binding protein RAP1 in complex with DNA provides the first insight into telomeric UNA recognition, RAP1 binds to DNA via two Myb/homeodomain-like motifs, which are DNA-binding folds previously identified in transcription factors, This, together with the finding that human TRF1 and other telomere-binding factors contain Myb-like motifs, has led us to speculate that a conserved protein fold might be used for telomeric DNA recognition.

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页码：43 / 47

页数：5

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