Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus

被引：86

作者：

Straube, T ^{[1
]}

Korz, V ^{[1
]}

Frey, JU ^{[1
]}

机构：

[1] Leibniz Inst Neurobiol, Dept Neurophysiol, D-39118 Magdeburg, Germany

来源：

NEUROSCIENCE LETTERS | 2003年 / 344卷 / 01期

关键词：

dentate gyrus learning; memory formation; long-term potentiation; LTP-reversal; LTP-reinforcement; novelty; late-LTP; HIPPOCAMPUS; MECHANISMS; MEMORY; NORADRENALINE; REINFORCEMENT; STIMULATION; INDUCTION; AROUSAL;

D O I：

10.1016/S0304-3940(03)00349-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f = 200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to I min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and enhancing factors may be relevant for the modulation of memory formation by novelty. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：5 / 8

页数：4

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