Anti-Helicobacter pylori agents.: 2.: Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

被引：16

作者：

Katsura, Y

Nishino, S

Tomishi, T

Sakane, K

Matsumoto, Y

Ishikawa, H

Takasugi, H

机构：

[1] Fujisawa Pharmaceut Co Ltd, Res Planning Res Div, Med Chem Res Labs, Yodogawa Ku, Osaka 532, Japan

[2] Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Yodogawa Ku, Osaka 532, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

antimicrobial compounds; gastrointestinal activity;

D O I：

10.1016/S0960-894X(98)00206-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1307 / 1312

页数：6

共 16 条

[1] ULCERS AS AN INFECTIOUS-DISEASE
ALPER, J
[J]. SCIENCE, 1993, 260 (5105) : 159 - 160
[2] ATESHKADI A, 1993, CLIN PHARMACY, V12, P34
[3] Eradication of Helicobacter pylori
Axon, ATR
[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1996, 31 : 47 - 53
[4] Helicobacter pylori and peptic ulcer disease
Blum, AL
[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1996, 31 : 24 - 27
[5] CHIBA N, 1992, AM J GASTROENTEROL, V87, P1716
[6] DOOLEY CP, 1991, ALIMENT PHARM THERAP, V5, P129
[7] THE ROLE AND TREATMENT OF HELICOBACTER-PYLORI INFECTION IN PEPTIC-ULCER DISEASE - A REVIEW OF THE RELATIONSHIP BETWEEN HELICOBACTER-PYLORI INFECTION AND PEPTIC-ULCER DISEASE
FLETCHER, PJ
CRAIG, DQM
[J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 1993, 18 (05) : 311 - 316
[8] GLUPCZYNSKI Y, 1990, AM J GASTROENTEROL, V85, P1545
[9] HEATLEY RV, 1992, ALIMENT PHARM THERAP, V6, P291
[10] KATSURA Y, 1992, CHEM PHARM BULL, V40, P2432

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