C-reactive protein concentration distribution among US children and young adults: Findings from the National Health and Nutrition Examination Survey, 1999-2000

被引:125
作者
Ford, ES
Giles, WH
Myers, GL
Rifai, N
Ridker, PM
Mannino, DM
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30333 USA
[2] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA
[3] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30341 USA
[4] Harvard Univ, Sch Med, Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Cardiovasc Dis Program, Boston, MA 02115 USA
关键词
D O I
10.1373/49.8.1353
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: The distribution of C-reactive protein (CRP) concentrations among children and young adults in the US is not known at present. Methods: We used data from 3348 US children and young adults 3-19 years of age who participated in the National Health and Nutrition Examination Survey, 1999-2000, to describe the distribution of CRP concentrations, based on results obtained with a high-sensitivity latex-enhanced turbidimetric assay. Results: The range of CRP concentrations was 0.1-90.8 mg/L (mean, 1.6 mg/L; geometric mean, 0.5 mg/L; median, 0.4 mg/L). CRP concentrations increased with age. Females 16-19 years of age had higher concentrations than males in this age range (P = 0.003). Mexican Americans had the highest CRP concentrations among the three major race or ethnic groups (P <0.001). Conclusions: For the first time, these data describe the CRP concentration distribution among US children and young adults, based on results obtained with a high-sensitivity assay. (C) 2003 American Association for Clinical Chemistry.
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页码:1353 / 1357
页数:5
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